Ontology highlight
ABSTRACT:
SUBMITTER: De Luca A
PROVIDER: S-EPMC5808835 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
De Luca Andrea A Flandre Philippe P Dunn David D Zazzi Maurizio M Wensing Annemarie A Santoro Maria Mercedes MM Günthard Huldrych F HF Wittkop Linda L Kordossis Theodoros T Garcia Federico F Castagna Antonella A Cozzi-Lepri Alessandro A Churchill Duncan D De Wit Stéphane S Brockmeyer Norbert H NH Imaz Arkaitz A Mussini Cristina C Obel Niels N Perno Carlo Federico CF Roca Bernardino B Reiss Peter P Schülter Eugen E Torti Carlo C van Sighem Ard A Zangerle Robert R Descamps Diane D
The Journal of antimicrobial chemotherapy 20160128 5
<h4>Objectives</h4>The objective of this study was to improve the prediction of the impact of HIV-1 protease mutations in different viral subtypes on virological response to darunavir.<h4>Methods</h4>Darunavir-containing treatment change episodes (TCEs) in patients previously failing PIs were selected from large European databases. HIV-1 subtype B-infected patients were used as the derivation dataset and HIV-1 non-B-infected patients were used as the validation dataset. The adjusted association ...[more]