Ontology highlight
ABSTRACT:
SUBMITTER: Lee YW
PROVIDER: S-EPMC5808845 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Nature structural & molecular biology 20180122 2
The shelterin protein TRF2 assembles protective T loops at chromosome ends by stimulating intramolecular invasion of the telomeric G-rich single-stranded DNA (ssDNA) overhang into the duplex telomeric array. The other shelterin factor, TRF1, is thought to mainly facilitate telomeric dsDNA replication without directly participating in end protection. Here we show that in vitro human TRF2 stimulates invasion of G-rich TERRA-like RNA into telomeric dsDNA, leading to formation of telomeric RNA-DNA h ...[more]