Ontology highlight
ABSTRACT:
SUBMITTER: Jenkins RW
PROVIDER: S-EPMC5809290 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Jenkins Russell W RW Aref Amir R AR Lizotte Patrick H PH Ivanova Elena E Stinson Susanna S Zhou Chensheng W CW Bowden Michaela M Deng Jiehui J Liu Hongye H Miao Diana D He Meng Xiao MX Walker William W Zhang Gao G Tian Tian T Cheng Chaoran C Wei Zhi Z Palakurthi Sangeetha S Bittinger Mark M Vitzthum Hans H Kim Jong Wook JW Merlino Ashley A Quinn Max M Venkataramani Chandrasekar C Kaplan Joshua A JA Portell Andrew A Gokhale Prafulla C PC Phillips Bart B Smart Alicia A Rotem Asaf A Jones Robert E RE Keogh Lauren L Anguiano Maria M Stapleton Lance L Jia Zhiheng Z Barzily-Rokni Michal M Cañadas Israel I Thai Tran C TC Hammond Marc R MR Vlahos Raven R Wang Eric S ES Zhang Hua H Li Shuai S Hanna Glenn J GJ Huang Wei W Hoang Mai P MP Piris Adriano A Eliane Jean-Pierre JP Stemmer-Rachamimov Anat O AO Cameron Lisa L Su Mei-Ju MJ Shah Parin P Izar Benjamin B Thakuria Manisha M LeBoeuf Nicole R NR Rabinowits Guilherme G Gunda Viswanath V Parangi Sareh S Cleary James M JM Miller Brian C BC Kitajima Shunsuke S Thummalapalli Rohit R Miao Benchun B Barbie Thanh U TU Sivathanu Vivek V Wong Joshua J Richards William G WG Bueno Raphael R Yoon Charles H CH Miret Juan J Herlyn Meenhard M Garraway Levi A LA Van Allen Eliezer M EM Freeman Gordon J GJ Kirschmeier Paul T PT Lorch Jochen H JH Ott Patrick A PA Hodi F Stephen FS Flaherty Keith T KT Kamm Roger D RD Boland Genevieve M GM Wong Kwok-Kin KK Dornan David D Paweletz Cloud Peter CP Barbie David A DA
Cancer discovery 20171103 2
<i>Ex vivo</i> systems that incorporate features of the tumor microenvironment and model the dynamic response to immune checkpoint blockade (ICB) may facilitate efforts in precision immuno-oncology and the development of effective combination therapies. Here, we demonstrate the ability to interrogate <i>ex vivo</i> response to ICB using murine- and patient-derived organotypic tumor spheroids (MDOTS/PDOTS). MDOTS/PDOTS isolated from mouse and human tumors retain autologous lymphoid and myeloid ce ...[more]