Integrating Systems Biology and an Ex Vivo Human Tumor Model Elucidates PD-1 Blockade Response Dynamics.
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ABSTRACT:
SUBMITTER: Smalley M
PROVIDER: S-EPMC7303667 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Publications
Integrating Systems Biology and an Ex Vivo Human Tumor Model Elucidates PD-1 Blockade Response Dynamics.
Smalley Munisha M Przedborski Michelle M Thiyagarajan Saravanan S Pellowe Moriah M Verma Amit A Brijwani Nilesh N Datta Debika D Jain Misti M Shanthappa Basavaraja U BU Kapoor Vidushi V Gopinath Kodaganur S KS Doval D C DC Sabitha K S KS Taroncher-Oldenburg Gaspar G Majumder Biswanath B Majumder Pradip P Kohandel Mohammad M Goldman Aaron A
iScience 20200602 6
Ex vivo human tumor models have emerged as promising, yet complex tools to study cancer immunotherapy response dynamics. Here, we present a strategy that integrates empirical data from an ex vivo human system with computational models to interpret the response dynamics of a clinically prescribed PD-1 inhibitor, nivolumab, in head and neck squamous cell carcinoma (HNSCC) biopsies (N = 50). Using biological assays, we show that drug-induced variance stratifies samples by T helper type 1 (Th1)-rela ...[more]
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