Ontology highlight
ABSTRACT:
SUBMITTER: Sato S
PROVIDER: S-EPMC5809579 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Sato Shigeto S Uchihara Toshiki T Fukuda Takahiro T Noda Sachiko S Kondo Hiromi H Saiki Shinji S Komatsu Masaaki M Uchiyama Yasuo Y Tanaka Keiji K Hattori Nobutaka N
Scientific reports 20180212 1
Inactivation of constitutive autophagy results in the formation of cytoplasmic inclusions in neurons, but the relationship between impaired autophagy and Lewy bodies (LBs) as well as the in vivo process of formation remains unknown. Synuclein, a component of LBs, is the defining characteristic of Parkinson's disease (PD). Here, we characterize dopamine (DA) neuron-specific autophagy-deficient mice and provide in vivo evidence for LB formation. Synuclein deposition is preceded by p62 and resulted ...[more]