Ontology highlight
ABSTRACT:
SUBMITTER: Coupe B
PROVIDER: S-EPMC3278575 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Coupé Bérengère B Ishii Yuko Y Dietrich Marcelo O MO Komatsu Masaaki M Horvath Tamas L TL Bouret Sebastien G SG
Cell metabolism 20120126 2
The hypothalamic melanocortin system, which includes neurons that produce pro-opiomelanocortin (POMC)-derived peptides, is a major negative regulator of energy balance. POMC neurons begin to acquire their unique properties during neonatal life. The formation of functional neural systems requires massive cytoplasmic remodeling that may involve autophagy, an important intracellular mechanism for the degradation of damaged proteins and organelles. Here we investigated the functional and structural ...[more]