Ontology highlight
ABSTRACT:
SUBMITTER: Stadhouders R
PROVIDER: S-EPMC5810905 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Nature genetics 20180115 2
Chromosomal architecture is known to influence gene expression, yet its role in controlling cell fate remains poorly understood. Reprogramming of somatic cells into pluripotent stem cells (PSCs) by the transcription factors (TFs) OCT4, SOX2, KLF4 and MYC offers an opportunity to address this question but is severely limited by the low proportion of responding cells. We have recently developed a highly efficient reprogramming protocol that synchronously converts somatic into pluripotent stem cell ...[more]