Ontology highlight
ABSTRACT:
SUBMITTER: Chen H
PROVIDER: S-EPMC6119122 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Chen Hongtao H Levo Michal M Barinov Lev L Fujioka Miki M Jaynes James B JB Gregor Thomas T
Nature genetics 20180723 9
A long-standing question in gene regulation is how remote enhancers communicate with their target promoters, and specifically how chromatin topology dynamically relates to gene activation. Here, we combine genome editing and multi-color live imaging to simultaneously visualize physical enhancer-promoter interaction and transcription at the single-cell level in Drosophila embryos. By examining transcriptional activation of a reporter by the endogenous even-skipped enhancers, which are located 150 ...[more]