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Visible light C-H amidation of heteroarenes with benzoyl azides.

ABSTRACT: Benzoyl azides were used for the direct and atom economic C-H amidation of electron rich heteroarenes in the presence of phosphoric acid, a photocatalyst and visible light. Hetero-aromatic amides are obtained in good yields at very mild reaction conditions with dinitrogen as the only by-product. The reaction allows the use of aryl-, heteroaryl- or alkenyl acyl azides and has a wide scope for heteroarenes, including pyrroles, indole, furan, benzofuran and thiophene giving good regio-selectivities and yields.

SUBMITTER: Brachet E

PROVIDER: S-EPMC5811135 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature

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Visible light C-H amidation of heteroarenes with benzoyl azides.

Brachet E E Ghosh T T Ghosh I I König B B

Chemical science 20141030 2

Benzoyl azides were used for the direct and atom economic C-H amidation of electron rich heteroarenes in the presence of phosphoric acid, a photocatalyst and visible light. Hetero-aromatic amides are obtained in good yields at very mild reaction conditions with dinitrogen as the only by-product. The reaction allows the use of aryl-, heteroaryl- or alkenyl acyl azides and has a wide scope for heteroarenes, including pyrroles, indole, furan, benzofuran and thiophene giving good regio-selectivities ...[more]

PMID: 29560185

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