Ontology highlight
ABSTRACT:
SUBMITTER: Islam RM
PROVIDER: S-EPMC5811490 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Islam Rafique M RM Pourmousa Mohsen M Sviridov Denis D Gordon Scott M SM Neufeld Edward B EB Freeman Lita A LA Perrin B Scott BS Pastor Richard W RW Remaley Alan T AT
Scientific reports 20180213 1
Peptides mimicking the major protein of highdensity lipoprotein (HDL), apolipoprotein A-I (apoA-I), are promising therapeutics for cardiovascular diseases. Similar to apoA-I, their atheroprotective property is attributed to their ability to form discoidal HDL-like particles by extracting cellular cholesterol and phospholipids from lipid microdomains created by the ABCA1 transporter in a process called cholesterol efflux. The structural features of peptides that enable cholesterol efflux are not ...[more]