Ontology highlight
ABSTRACT:
SUBMITTER: Ferreira PG
PROVIDER: S-EPMC5811508 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Ferreira Pedro G PG Muñoz-Aguirre Manuel M Reverter Ferran F Sá Godinho Caio P CP Sousa Abel A Amadoz Alicia A Sodaei Reza R Hidalgo Marta R MR Pervouchine Dmitri D Carbonell-Caballero Jose J Nurtdinov Ramil R Breschi Alessandra A Amador Raziel R Oliveira Patrícia P Çubuk Cankut C Curado João J Aguet François F Oliveira Carla C Dopazo Joaquin J Sammeth Michael M Ardlie Kristin G KG Guigó Roderic R
Nature communications 20180213 1
Post-mortem tissues samples are a key resource for investigating patterns of gene expression. However, the processes triggered by death and the post-mortem interval (PMI) can significantly alter physiologically normal RNA levels. We investigate the impact of PMI on gene expression using data from multiple tissues of post-mortem donors obtained from the GTEx project. We find that many genes change expression over relatively short PMIs in a tissue-specific manner, but this potentially confounding ...[more]