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1?,25-dihydroxyvitamin D3 mitigates cancer cell mediated mitochondrial dysfunction in human skeletal muscle cells.


ABSTRACT: Cancer cachexia is associated with muscle weakness and atrophy. We investigated whether 1?,25-dihydroxyvitamin D3 (1?,25(OH)2D3), which has previously been shown to increase skeletal myoblast oxygen consumption rate, could reverse the deleterious effects of tumor cell conditioned medium on myoblast function. Conditioned medium from Lewis lung carcinoma (LLC1) cells inhibits oxygen consumption, increases mitochondrial fragmentation, inhibits pyruvate dehydrogenase activity, and enhances proteasomal activity in human skeletal muscle myoblasts. 1?,25(OH)2D3 reverses the tumor cell-mediated changes in mitochondrial oxygen consumption and proteasomal activity, without changing pyruvate dehydrogenase activity. 1?,25(OH)2D3 might be useful in treatment of weakness seen in association with CC.

SUBMITTER: Ryan ZC 

PROVIDER: S-EPMC5812288 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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1α,25-dihydroxyvitamin D<sub>3</sub> mitigates cancer cell mediated mitochondrial dysfunction in human skeletal muscle cells.

Ryan Zachary C ZC   Craig Theodore A TA   Wang Xuewei X   Delmotte Philippe P   Salisbury Jeffrey L JL   Lanza Ian R IR   Sieck Gary C GC   Kumar Rajiv R  

Biochemical and biophysical research communications 20180201 2


Cancer cachexia is associated with muscle weakness and atrophy. We investigated whether 1α,25-dihydroxyvitamin D<sub>3</sub> (1α,25(OH)<sub>2</sub>D<sub>3</sub>), which has previously been shown to increase skeletal myoblast oxygen consumption rate, could reverse the deleterious effects of tumor cell conditioned medium on myoblast function. Conditioned medium from Lewis lung carcinoma (LLC1) cells inhibits oxygen consumption, increases mitochondrial fragmentation, inhibits pyruvate dehydrogenase  ...[more]

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