Ontology highlight
ABSTRACT:
SUBMITTER: Ryan ZC
PROVIDER: S-EPMC5812288 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Ryan Zachary C ZC Craig Theodore A TA Wang Xuewei X Delmotte Philippe P Salisbury Jeffrey L JL Lanza Ian R IR Sieck Gary C GC Kumar Rajiv R
Biochemical and biophysical research communications 20180201 2
Cancer cachexia is associated with muscle weakness and atrophy. We investigated whether 1α,25-dihydroxyvitamin D<sub>3</sub> (1α,25(OH)<sub>2</sub>D<sub>3</sub>), which has previously been shown to increase skeletal myoblast oxygen consumption rate, could reverse the deleterious effects of tumor cell conditioned medium on myoblast function. Conditioned medium from Lewis lung carcinoma (LLC1) cells inhibits oxygen consumption, increases mitochondrial fragmentation, inhibits pyruvate dehydrogenase ...[more]