Expression of nephronectin is enhanced by 1?,25-dihydroxyvitamin D3.
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ABSTRACT:
SUBMITTER: Hiranuma K
PROVIDER: S-EPMC5011489 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Publications
Expression of nephronectin is enhanced by 1α,25-dihydroxyvitamin D3.
Hiranuma Katsuhiro K Yamada Atsushi A Kurosawa Tamaki T Aizawa Ryo R Suzuki Dai D Saito Yoshiro Y Nagahama Ryo R Ikehata Mikiko M Tsukasaki Masayuki M Morimura Naoko N Chikazu Daichi D Maki Koutaro K Shirota Tatsuo T Takami Masamichi M Yamamoto Matsuo M Iijima Takehiko T Kamijo Ryutaro R
FEBS open bio 20160713 9
The extracellular matrix protein nephronectin (Npnt), also called POEM, is considered to play critical roles as an adhesion molecule in development and functions of various tissues, such as the kidneys, liver, and bone. In the present study, we examined the molecular mechanism of Npnt gene expression and found that vitamin D3 (1α,25-dihydroxyvitamin D3,VD 3) strongly enhanced Npnt mRNA expression in MC3T3-E1 cells from a mouse osteoblastic cell line. The VD 3-induced increase in Npnt expression ...[more]
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