Ontology highlight
ABSTRACT:
SUBMITTER: Sok D
PROVIDER: S-EPMC5812458 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Sok Devin D Le Khoa M KM Vadnais Melissa M Saye-Francisco Karen L KL Jardine Joseph G JG Torres Jonathan L JL Berndsen Zachary T ZT Kong Leopold L Stanfield Robyn R Ruiz Jennifer J Ramos Alejandra A Liang Chi-Hui CH Chen Patricia L PL Criscitiello Michael F MF Mwangi Waithaka W Wilson Ian A IA Ward Andrew B AB Smider Vaughn V VV Burton Dennis R DR
Nature 20170720 7665
No immunogen to date has reliably elicited broadly neutralizing antibodies to HIV in humans or animal models. Advances in the design of immunogens that antigenically mimic the HIV envelope glycoprotein (Env), such as the soluble cleaved trimer BG505 SOSIP, have improved the elicitation of potent isolate-specific antibody responses in rabbits and macaques, but so far failed to induce broadly neutralizing antibodies. One possible reason for this failure is that the relevant antibody repertoires ar ...[more]