Ontology highlight
ABSTRACT:
SUBMITTER: Huang D
PROVIDER: S-EPMC7673113 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Huang Deli D Tran Jenny Tuyet JT Olson Alex A Vollbrecht Thomas T Tenuta Mary M Guryleva Mariia V MV Fuller Roberta P RP Schiffner Torben T Abadejos Justin R JR Couvrette Lauren L Blane Tanya R TR Saye Karen K Li Wenjuan W Landais Elise E Gonzalez-Martin Alicia A Schief William W Murrell Ben B Burton Dennis R DR Nemazee David D Voss James E JE
Nature communications 20201117 1
HIV broadly neutralizing antibodies (bnAbs) can suppress viremia and protect against HIV infection. However, their elicitation is made difficult by low frequencies of appropriate precursor B cell receptors and the complex maturation pathways required to generate bnAbs from these precursors. Antibody genes can be engineered into B cells for expression as both a functional antigen receptor on cell surfaces and as secreted antibody. Here, we show that HIV bnAb-engineered primary mouse B cells can b ...[more]