Ontology highlight
ABSTRACT:
SUBMITTER: Gray DL
PROVIDER: S-EPMC5813016 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Gray David L DL Allen John A JA Mente Scot S O'Connor Rebecca E RE DeMarco George J GJ Efremov Ivan I Tierney Patrick P Volfson Dmitri D Davoren Jennifer J Guilmette Edward E Salafia Michelle M Kozak Rouba R Ehlers Michael D MD
Nature communications 20180214 1
Selective activation of dopamine D1 receptors (D1Rs) has been pursued for 40 years as a therapeutic strategy for neurologic and psychiatric diseases due to the fundamental role of D1Rs in motor function, reward processing, and cognition. All known D1R-selective agonists are catechols, which are rapidly metabolized and desensitize the D1R after prolonged exposure, reducing agonist response. As such, drug-like selective D1R agonists have remained elusive. Here we report a novel series of selective ...[more]