Ontology highlight
ABSTRACT:
SUBMITTER: Martini ML
PROVIDER: S-EPMC6688508 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20190327 7
G protein-coupled receptors (GPCRs) are capable of downstream signaling through distinct noncanonical pathways such as β-arrestins in addition to the canonical G protein-dependent pathways. GPCR ligands that differentially activate the downstream signaling pathways are termed functionally selective or biased ligands. A class of novel non-catechol G protein-biased agonists of the dopamine D<sub>1</sub> receptor (D<sub>1</sub>R) was recently disclosed. We conducted the first comprehensive structur ...[more]