Ontology highlight
ABSTRACT:
SUBMITTER: Li XF
PROVIDER: S-EPMC5813210 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Nature communications 20180214 1
The global spread of Zika virus (ZIKV) and its unexpected association with congenital defects necessitates the rapid development of a safe and effective vaccine. Here we report the development and characterization of a recombinant chimeric ZIKV vaccine candidate (termed ChinZIKV) that expresses the prM-E proteins of ZIKV using the licensed Japanese encephalitis live-attenuated vaccine SA14-14-2 as the genetic backbone. ChinZIKV retains its replication activity and genetic stability in vitro, whi ...[more]