Ontology highlight
ABSTRACT:
SUBMITTER: Luo X
PROVIDER: S-EPMC5813235 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Luo Xiao X Li Meng M Zhan Kaiyu K Yang Wei W Zhang Lihe L Wang KeWei K Yu Peilin P Zhang Liangren L
Chemical biology & drug design 20171115 2
Transient receptor potential melastatin-2 (TRPM2) channel critical for monitoring internal body temperature is implicated in the pathological processes such as neurodegeneration. However, lacking selective and potent TRPM2 inhibitors impedes investigation and validation of the channel as a drug target. To discover novel and selective TRPM2 inhibitors, a series of adenosine 5'-diphosphoribose analogues were synthesized, and their activities and selectivity were evaluated. Whole-cell patch-clamp r ...[more]