Ontology highlight
ABSTRACT:
SUBMITTER: Jang Y
PROVIDER: S-EPMC6477016 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Jang Yongwoo Y Lee Byeongjun B Kim Hyungsup H Jung Seungmoon S Lee Sung Hoon SH Lee So-Young SY Jeon Ji Hyun JH Kim In-Beom IB Lee Seo-Ho SH Kim Byung-Ju BJ Kim Uh-Hyun UH Lee Yunjong Y Kim Sung Min SM Jeon Daejong D Oh Uhtaek U
Molecular neurobiology 20180913 5
TRPM2 a cation channel is also known to work as an enzyme that hydrolyzes highly reactive, neurotoxic ADP-ribose (ADPR). Although ADPR is hydrolyzed by NUT9 pyrophosphatase in major organs, the enzyme is defective in the brain. The present study questions the role of TRPM2 in the catabolism of ADPR in the brain. Genetic ablation of Trpm2 results in the disruption of ADPR catabolism that leads to the accumulation of ADPR and reduction in AMP. Trpm2<sup>-/-</sup> mice elicit the reduction in autop ...[more]