Ontology highlight
ABSTRACT:
SUBMITTER: Glaeser K
PROVIDER: S-EPMC5813261 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
The EMBO journal 20180129 4
Active regulation of protein abundance is an essential strategy to modulate cellular signaling pathways. Within the Wnt signaling cascade, regulated degradation of β-catenin by the ubiquitin-proteasome system (UPS) affects the outcome of canonical Wnt signaling. Here, we found that abundance of the Wnt cargo receptor Evi (Wls/GPR177), which is required for Wnt protein secretion, is also regulated by the UPS through endoplasmic reticulum (ER)-associated degradation (ERAD). In the absence of Wnt l ...[more]