Affinity proteomic profiling of plasma for proteins associated to area-based mammographic breast density.

ABSTRACT: BACKGROUND:Mammographic breast density is one of the strongest risk factors for breast cancer, but molecular understanding of how breast density relates to cancer risk is less complete. Studies of proteins in blood plasma, possibly associated with mammographic density, are well-suited as these allow large-scale analyses and might shed light on the association between breast cancer and breast density. METHODS:Plasma samples from 1329 women in the Swedish KARMA project, without prior history of breast cancer, were profiled with antibody suspension bead array (SBA) assays. Two sample sets comprising 729 and 600 women were screened by two different SBAs targeting a total number of 357 proteins. Protein targets were selected through searching the literature, for either being related to breast cancer or for being linked to the extracellular matrix. Association between proteins and absolute area-based breast density (AD) was assessed by quantile regression, adjusting for age and body mass index (BMI). RESULTS:Plasma profiling revealed linear association between 20 proteins and AD, concordant in the two sets of samples (p

SUBMITTER: Bystrom S 

PROVIDER: S-EPMC5813412 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature