Ontology highlight
ABSTRACT:
SUBMITTER: Osada N
PROVIDER: S-EPMC5814224 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Osada Naoki N Kikuchi Jiro J Umehara Takashi T Sato Shin S Urabe Masashi M Abe Tomoyuki T Hayashi Nakanobu N Sugitani Masahiko M Hanazono Yutaka Y Furukawa Yusuke Y
Oncotarget 20180108 5
Human induced pluripotent stem cells (hiPSCs) are creating great expectations for regenerative medicine. However, safety strategies must be put in place to guard against teratoma formation after transplantation of hiPSC-derived cells into patients. Recent studies indicate that epigenetic regulators act at the initial step of tumorigenesis. Using gain-of-function and loss-of-function approaches, we show here that the expression and function of lysine-specific demethylase 1 (LSD1) are tightly regu ...[more]