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Biomimetic Desymmetrization of a Carboxylic Acid.


ABSTRACT: The enantioselective desymmetrization of carboxylic acids by chiral Brønsted base catalysis is reported, leading to bridged bicyclic lactones with up to 94% ee. Crystallographic analysis of a substrate-catalyst complex suggests an origin of stereocontrol, reminiscent of functional Brønsted bases in biological settings, and enabled reaction optimization. The products contain an all-carbon quaternary stereocenter and can be derivatized to functionalized cyclopentanes.

SUBMITTER: Knowe MT 

PROVIDER: S-EPMC5814305 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Biomimetic Desymmetrization of a Carboxylic Acid.

Knowe Matthew T MT   Danneman Michael W MW   Sun Sarah S   Pink Maren M   Johnston Jeffrey N JN  

Journal of the American Chemical Society 20180205 6


The enantioselective desymmetrization of carboxylic acids by chiral Brønsted base catalysis is reported, leading to bridged bicyclic lactones with up to 94% ee. Crystallographic analysis of a substrate-catalyst complex suggests an origin of stereocontrol, reminiscent of functional Brønsted bases in biological settings, and enabled reaction optimization. The products contain an all-carbon quaternary stereocenter and can be derivatized to functionalized cyclopentanes. ...[more]

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