Unknown

Dataset Information

0

Biomimetic Desymmetrization of a Carboxylic Acid.


ABSTRACT: The enantioselective desymmetrization of carboxylic acids by chiral Brønsted base catalysis is reported, leading to bridged bicyclic lactones with up to 94% ee. Crystallographic analysis of a substrate-catalyst complex suggests an origin of stereocontrol, reminiscent of functional Brønsted bases in biological settings, and enabled reaction optimization. The products contain an all-carbon quaternary stereocenter and can be derivatized to functionalized cyclopentanes.

SUBMITTER: Knowe MT 

PROVIDER: S-EPMC5814305 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

altmetric image

Publications

Biomimetic Desymmetrization of a Carboxylic Acid.

Knowe Matthew T MT   Danneman Michael W MW   Sun Sarah S   Pink Maren M   Johnston Jeffrey N JN  

Journal of the American Chemical Society 20180205 6


The enantioselective desymmetrization of carboxylic acids by chiral Brønsted base catalysis is reported, leading to bridged bicyclic lactones with up to 94% ee. Crystallographic analysis of a substrate-catalyst complex suggests an origin of stereocontrol, reminiscent of functional Brønsted bases in biological settings, and enabled reaction optimization. The products contain an all-carbon quaternary stereocenter and can be derivatized to functionalized cyclopentanes. ...[more]

Similar Datasets

| S-EPMC4497603 | biostudies-literature
2007-03-01 | GSE5512 | GEO
| S-EPMC2977796 | biostudies-literature
2024-02-14 | GSE224822 | GEO
| S-EPMC6161831 | biostudies-literature
| S-EPMC2961561 | biostudies-literature
| S-EPMC2983594 | biostudies-literature
| S-EPMC2968855 | biostudies-literature
| S-EPMC2780433 | biostudies-literature
| S-EPMC2968332 | biostudies-literature