Ontology highlight
ABSTRACT:
SUBMITTER: Knowe MT
PROVIDER: S-EPMC5814305 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Knowe Matthew T MT Danneman Michael W MW Sun Sarah S Pink Maren M Johnston Jeffrey N JN
Journal of the American Chemical Society 20180205 6
The enantioselective desymmetrization of carboxylic acids by chiral Brønsted base catalysis is reported, leading to bridged bicyclic lactones with up to 94% ee. Crystallographic analysis of a substrate-catalyst complex suggests an origin of stereocontrol, reminiscent of functional Brønsted bases in biological settings, and enabled reaction optimization. The products contain an all-carbon quaternary stereocenter and can be derivatized to functionalized cyclopentanes. ...[more]