Ontology highlight
ABSTRACT:
SUBMITTER: Grill S
PROVIDER: S-EPMC5815312 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Grill Sherilyn S Tesmer Valerie M VM Nandakumar Jayakrishnan J
Cell reports 20180101 5
Telomerase recruitment to telomeres and enzymatic processivity are mediated by TPP1, an essential component of telomere integrity and telomerase function. A surface on the OB domain of TPP1 called the TEL patch is critical for TPP1's telomerase-associated functions. Here, we identify a separate region in the N terminus of the OB domain (termed NOB) of TPP1 that, like the TEL patch, is essential for telomerase repeat addition processivity in vitro as well as telomerase recruitment to telomeres an ...[more]