Ontology highlight
ABSTRACT:
SUBMITTER: Stubblefield JJ
PROVIDER: S-EPMC5815321 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Stubblefield Jeremy J JJ Gao Peng P Kilaru Gokhul G Mukadam Bilal B Terrien Jeremy J Green Carla B CB
Cell reports 20180101 5
The timing of food intake and nutrient utilization is critical to health and regulated partly by the circadian clock. Increased amplitude of circadian oscillations and metabolic output has been found to improve health in diabetic and obesity mouse models. Here, we report a function for the circadian deadenylase Nocturnin as a regulator of metabolic amplitude across the day/night cycle and in response to nutrient challenge. We show that mice lacking Nocturnin (Noct<sup>-/-</sup>) display signific ...[more]