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Simultaneous Polymerization and Polypeptide Particle Production via Reactive Spray-Drying.

ABSTRACT: A method for producing polypeptide particles via in situ polymerization of N-carboxyanhydrides during spray-drying has been developed. This method was enabled by the development of a fast and robust synthetic pathway to polypeptides using 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) as an initiator for the ring-opening polymerization of N-carboxyanhydrides. The polymerizations finished within 5 s and proved to be very tolerant toward impurities such as amino acid salts and water. The formed particles were prepared by mixing the monomer, N-carboxyanhydride of l-glutamic acid benzyl ester (NCAGlu) and the initiator (DBU) during the atomization process in the spray-dryer and were spherical with a size of ?1 ?m. This method combines two steps; making it a straightforward process that facilitates the production of polypeptide particles. Hence, it furthers the use of spray-drying and polypeptide particles in the pharmaceutical industry.

SUBMITTER: Glavas L

PROVIDER: S-EPMC5815657 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature

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Simultaneous Polymerization and Polypeptide Particle Production via Reactive Spray-Drying.

Glavas Lidija L Odelius Karin K Albertsson Ann-Christine AC

Biomacromolecules 20160802 9

A method for producing polypeptide particles via in situ polymerization of N-carboxyanhydrides during spray-drying has been developed. This method was enabled by the development of a fast and robust synthetic pathway to polypeptides using 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) as an initiator for the ring-opening polymerization of N-carboxyanhydrides. The polymerizations finished within 5 s and proved to be very tolerant toward impurities such as amino acid salts and water. The formed particle ...[more]

PMID: 27445061

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