Ontology highlight
ABSTRACT:
SUBMITTER: Norquist BM
PROVIDER: S-EPMC5815909 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Norquist Barbara M BM Brady Mark F MF Harrell Maria I MI Walsh Tom T Lee Ming K MK Gulsuner Suleyman S Bernards Sarah S SS Casadei Silvia S Burger Robert A RA Tewari Krishnansu S KS Backes Floor F Mannel Robert S RS Glaser Gretchen G Bailey Cheryl C Rubin Stephen S Soper John J Lankes Heather A HA Ramirez Nilsa C NC King Mary Claire MC Birrer Michael J MJ Swisher Elizabeth M EM
Clinical cancer research : an official journal of the American Association for Cancer Research 20171130 4
<b>Purpose:</b> We hypothesized that mutations in homologous recombination repair (HRR) genes beyond <i>BRCA1</i> and <i>BRCA2</i> improve outcomes for ovarian carcinoma patients treated with platinum therapy and would impact the relative benefit of adding prolonged bevacizumab.<b>Experimental Design:</b> We sequenced DNA from blood and/or neoplasm from 1,195 women enrolled in GOG-0218, a randomized phase III trial in advanced ovarian carcinoma of bevacizumab added to carboplatin and paclitaxel. ...[more]