Ontology highlight
ABSTRACT:
SUBMITTER: Moore-Morris T
PROVIDER: S-EPMC5815911 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Moore-Morris Thomas T Cattaneo Paola P Guimarães-Camboa Nuno N Bogomolovas Julius J Cedenilla Marta M Banerjee Indroneal I Ricote Mercedes M Kisseleva Tatiana T Zhang Lunfeng L Gu Yusu Y Dalton Nancy D ND Peterson Kirk L KL Chen Ju J Pucéat Michel M Evans Sylvia M SM
Circulation research 20171221 4
<h4>Rationale</h4>Myocardial infarction is a major cause of adult mortality worldwide. The origin(s) of cardiac fibroblasts that constitute the postinfarct scar remain controversial, in particular the potential contribution of bone marrow lineages to activated fibroblasts within the scar.<h4>Objective</h4>The aim of this study was to establish the origin(s) of infarct fibroblasts using lineage tracing and bone marrow transplants and a robust marker for cardiac fibroblasts, the Collagen1a1-green ...[more]