Ontology highlight
ABSTRACT:
SUBMITTER: Wright GEB
PROVIDER: S-EPMC5817389 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Wright G E B GEB Carleton B B Hayden M R MR Ross C J D CJD
The pharmacogenomics journal 20161025 1
Differences in response to medications have a strong genetic component. By leveraging publically available data, the spectrum of such genomic variation can be investigated extensively. Pharmacogenomic variation was extracted from the 1000 Genomes Project Phase 3 data (2504 individuals, 26 global populations). A total of 12 084 genetic variants were found in 120 pharmacogenes, with the majority (90.0%) classified as rare variants (global minor allele frequency <0.5%), with 52.9% being singletons. ...[more]