Dataset Information

Mouse protein coding diversity: What's left to discover?

ABSTRACT: For over a century, mice have been used to model human disease, leading to many fundamental discoveries about mammalian biology and the development of new therapies. Mouse genetics research has been further catalysed by a plethora of genomic resources developed in the last 20 years, including the genome sequence of C57BL/6J and more recently the first draft reference genomes for 16 additional laboratory strains. Collectively, the comparison of these genomes highlights the extreme diversity that exists at loci associated with the immune system, pathogen response, and key sensory functions, which form the foundation for dissecting phenotypic traits in vivo. We review the current status of the mouse genome across the diversity of the mouse lineage and discuss the value of mice to understanding human disease.

SUBMITTER: Lilue J

PROVIDER: S-EPMC6855407 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Mouse protein coding diversity: What's left to discover?

Lilue Jingtao J Shivalikanjli Anu A Adams David J DJ Keane Thomas M TM

PLoS genetics 20191114 11

For over a century, mice have been used to model human disease, leading to many fundamental discoveries about mammalian biology and the development of new therapies. Mouse genetics research has been further catalysed by a plethora of genomic resources developed in the last 20 years, including the genome sequence of C57BL/6J and more recently the first draft reference genomes for 16 additional laboratory strains. Collectively, the comparison of these genomes highlights the extreme diversity that ...[more]

PMID: 31725724

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Project description:The position of design elements on product packaging has been shown to exert a measurable impact on consumer perception across a number of different studies and product categories. Design elements previously found to influence the consumer through their positioning on the front of pack include product imagery, brand logos, text-based claims, and basic shapes. However, as yet, no empirical research has focused specifically on the relative position of transparent windows; despite the latter being an increasingly prevalent element of many modern packaging designs. This exploratory online study details an experimental investigation of how manipulating the position of a transparent window on a range of visually-presented, novel packaging designs influences consumer evaluations and judgements of the product seen within. Specifically, 110 participants rated 24 different packaging designs (across four product categories: granola, boxed chocolates, pasta, and lemon mousse; each with six window positions: in one of the four quadrants, the top half, or the bottom half) in a within-participants experimental design. Analyses were conducted using Friedman's tests and Hochberg procedure-adjusted Wilcoxon Signed-Rank Tests. Window position was found to be a non-trivial element of design, with a general preference for windows on the right-hand side being evidenced. Significantly higher scores for expected product tastiness and design attractiveness were consistently identified across all product categories when windows were positioned on the right- vs. left-hand side of the packaging. Effects on the perception of powerfulness, overall liking, quality, and willingness to purchase were identified, but were inconsistent across the different product categories. Very few effects of window verticality were identified, with expected weight of the product not being significantly influenced by window position. The implications of these findings for academics, designers, and brand managers are discussed, with future research directions highlighted.

Dataset Information

Mouse protein coding diversity: What's left to discover?

Publications

Mouse protein coding diversity: What's left to discover?

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