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The Use of Sentinel Lymph Node Biopsy in BRCA1/2 Mutation Carriers Undergoing Prophylactic Mastectomy: A Retrospective Consecutive Case-Series Study.


ABSTRACT: Introduction:Sentinel lymph node biopsy in prophylactic mastectomy is controversial. It avoids lymphadenectomy in occult carcinoma but is associated with increased morbidity. Women with BRCA mutations have a higher incidence of occult carcinoma and our objective was to assess the clinical utility of sentinel lymph node biopsy when these women undergo prophylactic mastectomy. Materials and Methods:Seven-year retrospective consecutive case-series study of women, with a BRCA deleterious mutation, admitted to prophylactic mastectomy, at our center. Breast MRI < 6 months before surgery was routine, unless contraindicated. Results:Fifty-seven patients (43% BRCA1; 57% BRCA2) underwent 80 prophylactic mastectomies. 72% of patients had had breast cancer treated before prophylactic mastectomy or synchronously to it. The occult carcinoma incidence was 5%, and half of the cases were invasive. SLNB was performed in 19% of the prophylactic mastectomies; none of these had tumor invasion. Women with invasive carcinoma who had not undergone sentinel lymph node biopsy were followed closely with axillary ultrasound. The median follow-up was 37 months, with no local recurrence; 1 patient died of primary tumor systemic relapse. Conclusions:Our data do not support this procedure for routine (in agreement with previous literature), in this high risk for occult carcinoma population.

SUBMITTER: Camara S 

PROVIDER: S-EPMC5817815 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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The Use of Sentinel Lymph Node Biopsy in <i>BRCA1/2</i> Mutation Carriers Undergoing Prophylactic Mastectomy: A Retrospective Consecutive Case-Series Study.

Câmara Sara S   Pereira Daniela D   André Saudade S   Mira Beatriz B   Vaz Fátima F   Oom Rodrigo R   Marques José Carlos JC   Leal de Faria João J   Rodrigues Dos Santos Catarina C  

International journal of breast cancer 20180101


<h4>Introduction</h4>Sentinel lymph node biopsy in prophylactic mastectomy is controversial. It avoids lymphadenectomy in occult carcinoma but is associated with increased morbidity. Women with BRCA mutations have a higher incidence of occult carcinoma and our objective was to assess the clinical utility of sentinel lymph node biopsy when these women undergo prophylactic mastectomy.<h4>Materials and methods</h4>Seven-year retrospective consecutive case-series study of women, with a BRCA deleteri  ...[more]

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