Ontology highlight
ABSTRACT:
SUBMITTER: Perales-Calvo J
PROVIDER: S-EPMC5817926 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Science advances 20180209 2
It is well established that chaperones modulate the protein folding free-energy landscape. However, the molecular determinants underlying chaperone-mediated mechanical folding remain largely elusive, primarily because the force-extended unfolded conformation fundamentally differs from that characterized in biochemistry experiments. We use single-molecule force-clamp spectroscopy, combined with molecular dynamics simulations, to study the effect that the Hsp70 system has on the mechanical folding ...[more]