Ontology highlight
ABSTRACT:
SUBMITTER: Choraghe RP
PROVIDER: S-EPMC7063837 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Choraghe Rohan P RP Kołodziej Tomasz T Buser Alan A Rajfur Zenon Z Neumann Aaron K AK
Journal of cell science 20200302 5
Dendritic cell-associated C-type lectin 1 (Dectin-1, also known as CLEC7A) is an innate immune pattern recognition receptor that recognizes β-glucan on the <i>Candida albicans</i> cell wall. Recognition of β-glucan by immune cells leads to phagocytosis, oxidative burst, cytokine and chemokine production. We looked for specific mechanisms that coordinate phagocytosis downstream of Dectin-1 leading to actin reorganization and internalization of fungus. We found that stimulation of Dectin-1 by solu ...[more]