Ontology highlight
ABSTRACT:
SUBMITTER: Seeberger PH
PROVIDER: S-EPMC5819008 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Seeberger Peter H PH Pereira Claney L CL Khan Naeem N Xiao Guozhi G Diago-Navarro Elizabeth E Reppe Katrin K Opitz Bastian B Fries Bettina C BC Witzenrath Martin M
Angewandte Chemie (International ed. in English) 20171005 45
Hospital-acquired infections are an increasingly serious health concern. Infections caused by carpabenem-resistant Klebsiella pneumoniae (CR-Kp) are especially problematic, with a 50 % average survival rate. CR-Kp are isolated from patients with ever greater frequency, 7 % within the EU but 62 % in Greece. At a time when antibiotics are becoming less effective, no vaccines to protect from this severe bacterial infection exist. Herein, we describe the convergent [3+3] synthesis of the hexasacchar ...[more]