Ontology highlight
ABSTRACT:
SUBMITTER: Lisboa MP
PROVIDER: S-EPMC5651752 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Lisboa Marilda P MP Khan Naeem N Martin Christopher C Xu Fei-Fei FF Reppe Katrin K Geissner Andreas A Govindan Subramanian S Witzenrath Martin M Pereira Claney L CL Seeberger Peter H PH
Proceedings of the National Academy of Sciences of the United States of America 20171002 42
Glycoconjugate vaccines based on isolated capsular polysaccharide (CPS) save millions of lives annually by preventing invasive pneumococcal disease caused by <i>Streptococcus pneumoniae</i> Some components of the <i>S. pneumoniae</i> glycoconjugate vaccine Prevnar13 that contains CPS antigens from 13 serotypes undergo modifications or degradation during isolation and conjugation, resulting in production problems and lower efficacy. We illustrate how stable, synthetic oligosaccharide analogs of l ...[more]