Relationship of CT-quantified emphysema, small airways disease and bronchial wall dimensions with physiological, inflammatory and infective measures in COPD.

ABSTRACT:

Background

COPD is a complex, heterogeneous disease characterised by progressive development of airflow limitation. Spirometry provides little information about key aspects of pathology and is poorly related to clinical outcome, so other tools are required to investigate the disease. We sought to explore the relationships between quantitative CT analysis with functional, inflammatory and infective assessments of disease to identify the utility of imaging to stratify disease to better predict outcomes and disease response.

Methods

Patients from the AERIS study with moderate-very severe COPD underwent HRCT, with image analysis determining the quantity of emphysema (%LAA_<- 950), small airways disease (E/I MLD) and bronchial wall thickening (Pi10). At enrolment subjec

SUBMITTER: Ostridge K 

PROVIDER: S-EPMC5819274 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature