Ontology highlight
ABSTRACT:
SUBMITTER: Li S
PROVIDER: S-EPMC5819394 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Li Sicong S Guo Junhong J Reva Anna A Huang Fanglu F Xiong Binbin B Liu Yuanzhen Y Deng Zixin Z Leadlay Peter F PF Sun Yuhui Y
Proceedings of the National Academy of Sciences of the United States of America 20180122 6
Gentamicin C complex from <i>Micromonospora echinospora</i> remains a globally important antibiotic, and there is revived interest in the semisynthesis of analogs that might show improved therapeutic properties. The complex consists of five components differing in their methylation pattern at one or more sites in the molecule. We show here, using specific gene deletion and chemical complementation, that the gentamicin pathway up to the branch point is defined by the selectivity of the methyltran ...[more]