Ontology highlight
ABSTRACT:
SUBMITTER: Ban YH
PROVIDER: S-EPMC6488028 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Nature chemical biology 20190114 3
Gentamicin B (GB), a valuable starting material for the preparation of the semisynthetic aminoglycoside antibiotic isepamicin, is produced in trace amounts by the wild-type Micromonospora echinospora. Though the biosynthetic pathway to GB has remained obscure for decades, we have now identified three hidden pathways to GB production via seven hitherto unknown intermediates in M. echinospora. The narrow substrate specificity of a key glycosyltransferase and the C6'-amination enzymes, in combinati ...[more]