Ontology highlight
ABSTRACT:
SUBMITTER: Siracusa F
PROVIDER: S-EPMC5819416 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Siracusa Francesco F McGrath Mairi A MA Maschmeyer Patrick P Bardua Markus M Lehmann Katrin K Heinz Gitta G Durek Pawel P Heinrich Frederik F FF Mashreghi Mir-Farzin MF Chang Hyun-Dong HD Tokoyoda Koji K Radbruch Andreas A
Proceedings of the National Academy of Sciences of the United States of America 20180122 6
The bone marrow maintains memory CD4 T cells, which provide memory to systemic antigens. Here we demonstrate that memory CD4 T cells are reactivated by antigen in the bone marrow. In a secondary immune response, antigen-specific T cells of the bone marrow mobilize and aggregate in immune clusters together with MHC class II-expressing cells, mostly B lymphocytes. They proliferate vigorously and express effector cytokines, but they do not develop into follicular T-helper cells. Neither do the B ly ...[more]