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Antifungal and Cytotoxic ?-Resorcylic Acid Lactones from a Paecilomyces Species.

ABSTRACT: Eight new ?-resorcylic acid lactones (RALs), including the hypothemycin-type compounds paecilomycins N-P (1-3) and the radicicol-type metabolites dechloropochonin I (4), monocillins VI (5) and VII (6), 4'-hydroxymonocillin IV (7), and 4'-methoxymonocillin IV (8), along with nine known RALs (9-17), were isolated from the cultures of Paecilomyces sp. SC0924. Compounds 1 and 2 feature a novel 6/11/5 ring system, and 3 is the first 5'-keto RAL. The structures of 1-8 were elucidated on the basis of extensive spectroscopic analysis, X-ray diffraction analysis, and theoretical calculations of ECD spectra. Compounds 3, 5, and 6 exhibit cytotoxicity against MCF-7, A549, and HeLa cells, and compounds 5 and 7 display antifungal activity against Peronophythora litchii.

SUBMITTER: Xu L

PROVIDER: S-EPMC5819736 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Antifungal and Cytotoxic β-Resorcylic Acid Lactones from a Paecilomyces Species.

Xu Liangxiong L Wu Ping P Xue Jinghua J Molnar Istvan I Wei Xiaoyi X

Journal of natural products 20170727 8

Eight new β-resorcylic acid lactones (RALs), including the hypothemycin-type compounds paecilomycins N-P (1-3) and the radicicol-type metabolites dechloropochonin I (4), monocillins VI (5) and VII (6), 4'-hydroxymonocillin IV (7), and 4'-methoxymonocillin IV (8), along with nine known RALs (9-17), were isolated from the cultures of Paecilomyces sp. SC0924. Compounds 1 and 2 feature a novel 6/11/5 ring system, and 3 is the first 5'-keto RAL. The structures of 1-8 were elucidated on the basis of e ...[more]

PMID: 28749671

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