Ontology highlight
ABSTRACT:
SUBMITTER: Yang X
PROVIDER: S-EPMC5819834 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Yang Xiaodan X Hu Zhulong Z Fan Shanshan S Zhang Qiang Q Zhong Yi Y Guo Dong D Qin Yali Y Chen Mingzhou M
PLoS pathogens 20180207 2
Stress granules (SGs) contain stalled messenger ribonucleoprotein complexes and are related to the regulation of mRNA translation. Picornavirus infection can interfere with the formation of SGs. However, the detailed molecular mechanisms and functions of picornavirus-mediated regulation of SG formation are not clear. Here, we found that the 2A protease of a picornavirus, EV71, induced atypical stress granule (aSG), but not typical stress granule (tSG), formation via cleavage of eIF4GI. Furthermo ...[more]