Ontology highlight
ABSTRACT:
SUBMITTER: Hosmillo M
PROVIDER: S-EPMC6739877 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
eLife 20190812
Knowledge of the host factors required for norovirus replication has been hindered by the challenges associated with culturing human noroviruses. We have combined proteomic analysis of the viral translation and replication complexes with a CRISPR screen, to identify host factors required for norovirus infection. The core stress granule component G3BP1 was identified as a host factor essential for efficient human and murine norovirus infection, demonstrating a conserved function across the <i>Nor ...[more]