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Rapid changes in serum cytokines and chemokines in response to inactivated influenza vaccination.


ABSTRACT: BACKGROUND:The timing of host cytokine responses to influenza vaccination is poorly understood. OBJECTIVES:We examined serum cytokine kinetics following inactivated trivalent influenza vaccine (TIV) to better understand potential relationships between markers of inflammation and TIV-related side effects. PATIENTS/METHODS:Twenty healthy adult subjects received TIV. Cytokines/chemokines were assessed in intervals from 3 hours to 14 days. Antibody titers were measured at baseline and Day 14. RESULTS:Serum cytokine responses to TIV were evident as early as 3 hours post-immunization. Compared to baseline, IFN-? and IP-10 were significantly elevated 7 hours after TIV administration. Both remained elevated and peaked between 16 and 24 hours before returning to baseline by 44 hours post-vaccination. Although IL-8 levels were variable between subjects during the first 24 hours after TIV, by 44 hours, IL-8 was significantly lower compared to baseline. Interestingly, IL-8 levels remained significantly lower for up to 2 weeks after receiving TIV. Fifteen of 20 subjects reported mild adverse events. The one subject who reported moderate myalgias and injection site pain after vaccination displayed a distinctive, early cytokine response profile which included IL-6, IL-2, IL-8, IP-10, MCP-1, TNF-?, TARC, and MCP-4. CONCLUSIONS:Serum cytokines changed rapidly following TIV and generally peaked at 24 hours. Trivalent influenza vaccine-induced reductions in IL-8 occurred later (44 hours) and were sustained for 2 weeks. An outlier response coincided with the only moderate side effects to the vaccine. These data suggest that early cytokine/chemokine responses may provide additional insight into the pathogenesis of adverse events and immune reactivity to vaccination.

SUBMITTER: Talaat KR 

PROVIDER: S-EPMC5820426 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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Rapid changes in serum cytokines and chemokines in response to inactivated influenza vaccination.

Talaat Kawsar R KR   Halsey Neal A NA   Cox Amber B AB   Coles Christian L CL   Durbin Anna P AP   Ramakrishnan Amritha A   Bream Jay H JH  

Influenza and other respiratory viruses 20180104 2


<h4>Background</h4>The timing of host cytokine responses to influenza vaccination is poorly understood.<h4>Objectives</h4>We examined serum cytokine kinetics following inactivated trivalent influenza vaccine (TIV) to better understand potential relationships between markers of inflammation and TIV-related side effects.<h4>Patients/methods</h4>Twenty healthy adult subjects received TIV. Cytokines/chemokines were assessed in intervals from 3 hours to 14 days. Antibody titers were measured at basel  ...[more]

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