Ontology highlight
ABSTRACT:
SUBMITTER: You C
PROVIDER: S-EPMC5821042 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
You Chengcheng C Sun Yingming Y Zhang Shiyu S Tang Guiliang G Zhang Nannan N Li Chunyang C Tian Xiaoli X Ma Shijing S Luo Yuan Y Sun Wenjie W Wang Feng F Liu Xuefeng X Xiao Yu Y Gong Yan Y Zhang Junhong J Xie Conghua C
International journal of biological sciences 20180209 2
Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) has a specific antitumour activity against many malignant tumours. However, more than half of lung cancer cells are resistant to TRAIL-relevant drugs. Trichosanthin (TCS) is a traditional Chinese medicine with strong inhibitive effects on various malignancies. Nevertheless, its function on TRAIL resistance has not been revealed in non-small cell lung cancer (NSCLC). To examine the molecular mechanisms of TCS-induced TRAIL sensitivi ...[more]