Ontology highlight
ABSTRACT:
SUBMITTER: SenthilKumar G
PROVIDER: S-EPMC7272291 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
SenthilKumar Gopika G Fisher Michael M MM Skiba Justin H JH Miller Margot C MC Brennan Sean R SR Kaushik Saakshi S Bradley Samantha T ST Longhurst Colin A CA Buehler Darya D Nickel Kwangok P KP Iyer Gopal G Kimple Randall J RJ Baschnagel Andrew M AM
Molecular cancer therapeutics 20200505 6
FGFRs are commonly altered in non-small cell lung cancer (NSCLC). FGFRs activate multiple pathways including RAS/RAF/MAPK, PI3K/AKT, and STAT, which may play a role in the cellular response to radiation. We investigated the effects of combining the selective FGFR 1-3 tyrosine kinase inhibitor AZD4547 with radiation in cell line and xenograft models of NSCLC. NSCLC cell lines were assessed with proliferation, clonogenic survival, apoptosis, autophagy, cell cycle, and DNA damage signaling and repa ...[more]