Ontology highlight
ABSTRACT:
SUBMITTER: Yang R
PROVIDER: S-EPMC5821182 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Yang Ruojing R Wu Margaret M Lin Songnian S Nargund Ravi P RP Li Xinghai X Kelly Theresa T Yan Lin L Dai Ge G Qian Ying Y Dallas-Yang Qing Q Fischer Paul A PA Cui Yan Y Shen Xiaolan X Huo Pei P Feng Danqing Dennis DD Erion Mark D MD Kelley David E DE Mu James J
JCI insight 20180111 1
Hypoglycemia is commonly associated with insulin therapy, limiting both its safety and efficacy. The concept of modifying insulin to render its glucose-responsive release from an injection depot (of an insulin complexed exogenously with a recombinant lectin) was proposed approximately 4 decades ago but has been challenging to achieve. Data presented here demonstrate that mannosylated insulin analogs can undergo an additional route of clearance as result of their interaction with endogenous manno ...[more]