Ghrelin Protects Against Insulin-Induced Hypoglycemia in a Mouse Model of Type 1 Diabetes Mellitus.
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ABSTRACT:
SUBMITTER: Shankar K
PROVIDER: S-EPMC7518392 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
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Ghrelin Protects Against Insulin-Induced Hypoglycemia in a Mouse Model of Type 1 Diabetes Mellitus.
Shankar Kripa K Gupta Deepali D Mani Bharath K BK Findley Brianna G BG Osborne-Lawrence Sherri S Metzger Nathan P NP Liu Chen C Berglund Eric D ED Zigman Jeffrey M JM
Frontiers in endocrinology 20200911
Insulin-induced hypoglycemia is a major limiting factor in maintaining optimal blood glucose in patients with type 1 diabetes and advanced type 2 diabetes. Luckily, a counterregulatory response (1) system exists to help minimize and reverse hypoglycemia, although more studies are needed to better characterize its components. Recently, we showed that the hormone ghrelin is permissive for the normal CRR to insulin-induced hypoglycemia when assessed in mice without diabetes. Here, we tested the hyp ...[more]
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