Validation of highly accelerated real-time cardiac cine MRI with radial k-space sampling and compressed sensing in patients at 1.5T and 3T.

ABSTRACT: PURPOSE:To validate an optimal 12-fold accelerated real-time cine MRI pulse sequence with radial k-space sampling and compressed sensing (CS) in patients at 1.5T and 3T. METHODS:We used two strategies to reduce image artifacts arising from gradient delays and eddy currents in radial k-space sampling with balanced steady-state free precession readout. We validated this pulse sequence against a standard breath-hold cine sequence in two patient cohorts: a myocardial infarction (n?=?16) group at 1.5T and chronic kidney disease group (n?=?18) at 3T. Two readers independently performed visual analysis of 68 cine sets in four categories (myocardial definition, temporal fidelity, artifact, noise) on a 5-point Likert scale (1?=?nondiagnostic, 2?=?poor, 3?=?adequate or moderate, 4?=?good, 5?=?excellent). Another reader calculated left ventricular (LV) functional parameters, including ejection fraction. RESULTS:Compared with standard cine, real-time cine produced nonsignificantly different visually assessed scores, except for the following categories: 1) temporal fidelity scores were significantly lower (P?=?0.013) for real-time cine at both field strengths, 2) artifacts scores were significantly higher (P?=?0.013) for real-time cine at both field strengths, and 3) noise scores were significantly (P?=?0.013) higher for real-time cine at 1.5T. Standard and real-time cine pulse sequences produced LV functional parameters that were in good agreement (e.g., absolute mean difference in ejection fraction <4%). CONCLUSION:This study demonstrates that an optimal 12-fold, accelerated, real-time cine MRI pulse sequence using radial k-space sampling and CS produces good to excellent visual scores and relatively accurate LV functional parameters in patients at 1.5T and 3T. Magn Reson Med 79:2745-2751, 2018. © 2017 International Society for Magnetic Resonance in Medicine.

SUBMITTER: Haji-Valizadeh H 

PROVIDER: S-EPMC5821536 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature