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Trifluoromethyl Vinyl Sulfide: A Building Block for the Synthesis of CF₃S-Containing Isoxazolidines.

ABSTRACT: Trifluoromethyl vinyl sulfide, a potential building block for pharmaceutically and agrochemically relevant products, is prepared and used for the first time in high-pressure-mediated 1,3-dipolar cycloaddition reactions with nitrones to synthesize (trifluoromethyl)sulfanyl isoxazolidines.

SUBMITTER: Riesco-Dominguez A

PROVIDER: S-EPMC5822222 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Trifluoromethyl Vinyl Sulfide: A Building Block for the Synthesis of CF3S-Containing Isoxazolidines.

Riesco-Domínguez Alejandra A van de Wiel Jeroen J Hamlin Trevor A TA van Beek Bas B Lindell Stephen D SD Blanco-Ania Daniel D Bickelhaupt F Matthias FM Rutjes Floris P J T FPJT

The Journal of organic chemistry 20180130 4

Trifluoromethyl vinyl sulfide, a potential building block for pharmaceutically and agrochemically relevant products, is prepared and used for the first time in high-pressure-mediated 1,3-dipolar cycloaddition reactions with nitrones to synthesize (trifluoromethyl)sulfanyl isoxazolidines. ...[more]

PMID: 29320179

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